{"id":167,"date":"2017-03-05T17:46:03","date_gmt":"2017-03-05T16:46:03","guid":{"rendered":"http:\/\/molecularbionic.bplaced.net\/?page_id=167"},"modified":"2018-10-30T15:19:38","modified_gmt":"2018-10-30T14:19:38","slug":"research","status":"publish","type":"page","link":"https:\/\/molecularbionic.bplaced.net\/?page_id=167","title":{"rendered":"Research"},"content":{"rendered":"<style>\n.docxpressoPlugin {\n\tfont-size: 83.35%;\n}\n\n.h5p_layout {\n    box-sizing: content-box !important;\n}\n\n.h5p_layout *{\n    float: none;\n    text-align: initial;\n\tbox-sizing: border-box;\n}\n\/*to make sure that floating elements are always inside the document bounds*\/\n.h5p_layout:after {\n    content: \" \";\n    display: block;\n    height: 0;\n    clear: both;\n    visibility: hidden;\n}\n\/* a default layout for documents without maste styles *\/\n.h5p_default_layout {\n    margin-top: 3.6rem;\n    margin-left: 8.50464rem;\n    margin-bottom: 3.6rem;\n    margin-right: 8.50464rem;\n    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2;break-before: auto;border: none;text-align: left;writing-mode: lr-tb;vertical-align: baseline;margin-bottom: 0.1111in;line-height: 1;background-color: transparent;font-size: 11pt;}\n div#h5p_69f0ad3107f6c p span {font-family: Calibri;font-weight: normal;font-style: normal;text-transform: none;font-variant: normal;letter-spacing: normal;font-size: 11pt;background-color: transparent;text-decoration: none;text-decoration-color: font-color;language: de;country: DE;hyphenate: true;}\n\n<\/style>\n<div id=\"h5p_69f0ad3107f6c\"><section id=\"section_0\" class=\"h5p_layout h5p_page h5p_page_PL0\"><div class=\"PL0\"><p class=\"P1\"><span class=\"T2\">Molecular Bionics&#x200b;&#x200b;&nbsp;<\/span><span class=\"T3\">takes inspiration from biomolecules for the development of new technical concepts or&#x200b;&#x200b;&nbsp;<\/span><span class=\"T4\">of&#x200b;&#x200b;&nbsp;<\/span><span class=\"T5\">advanced materials.&#x200b;&#x200b;&nbsp;<\/span><a href=\"http:\/\/molecularbionic.bplaced.net\/?page_id=263&amp;preview=true\" target=\"_top\" title=\"\"><span class=\"T6\">Click here for exa<\/span><span id=\"_Hlt528674786\"\/><span id=\"_Hlt528674787\"\/><span class=\"T7\">m<\/span><span class=\"T8\">ples<\/span><\/a><span class=\"T9\">.<\/span><\/p><p class=\"P10\"><span class=\"T11\">Local structural heterogeneity<\/span><span class=\"T12\">&#x200b;&#x200b;&nbsp;is the common characteristic of biogenous structures like polyclonal antibodies, of biominerali<\/span><span class=\"T13\">z<\/span><span class=\"T14\">ation nucleators and of collagens, to name three of our targets. In order to identify the functional properties of the obs<\/span><span class=\"T15\">e<\/span><span class=\"T16\">r<\/span><span class=\"T17\">v<\/span><span class=\"T18\">ed microheterogeneity, we synthesize molecules with systematic structural variations one by one.<\/span><\/p><p class=\"P19\"><span class=\"T20\">Epitope&#x200b;&#x200b;&nbsp;<\/span><span class=\"T21\">B<\/span><span class=\"T22\">arcode<\/span><span class=\"T23\">: We constrain a minimal set of complementary conformers of a common primary peptide sequence to differentiate subpopulations of anti-CCP (Cyclic Citrullinated Peptide) antibodies. Our aim is the differentiation of individual antibody fingerprints of rheumatoid arthritis patients.<\/span>&#x200b;&#x200b;&nbsp;<a href=\"http:\/\/molecularbionic.bplaced.net\/?page_id=283\" target=\"_top\" title=\"\"><span class=\"T24\">Li<\/span><span id=\"_Hlt528675111\"\/><span id=\"_Hlt528675161\"\/><span class=\"T25\">n<\/span><span class=\"T26\">k<\/span><\/a><\/p><p class=\"P27\"><span class=\"T28\">Capped&#x200b;&#x200b;&nbsp;<\/span><span class=\"T29\">C<\/span><span class=\"T30\">ollagen<\/span><span class=\"T31\">: We synthesize capped collagens of uniform structures which are able form composite materials with silicic acid in analogy to the collagenous \u201cglass fibers\u201d of deep-sea sponges. All available collagens from natural sources are indefinite mixtures of diverse degraded proteins, only characterized by their average amino acid composition.&#x200b;&#x200b;&nbsp;<\/span><\/p><p class=\"P32\"><span class=\"T33\">Hyperfunctionalized&#x200b;&#x200b;&nbsp;<\/span><span class=\"T34\">P<\/span><span class=\"T35\">eptides<\/span><span class=\"T36\">: We pattern polycationic and\/or polyanionic charges on short peptide to investigate their silicification properties. Up to 8 phosphate esters and more than 20 amines are linked as post-translational modifications on the microheterogenic peptide Silaffin-1A1<\/span><span class=\"T37\">&#x200b;&#x200b;&nbsp;<\/span><span class=\"T38\">which nucleates&#x200b;&#x200b;&nbsp;<\/span><span class=\"T39\">biomineralization<\/span><span class=\"T40\">.<\/span>&#x200b;&#x200b;&nbsp;<a href=\"http:\/\/molecularbionic.bplaced.net\/?page_id=273&amp;preview=true\" target=\"_top\" title=\"\"><span class=\"T41\">Li<\/span><span id=\"_Hlt528675094\"\/><span class=\"T42\">n<\/span><span class=\"T43\">k<\/span><\/a><\/p><p class=\"P44\"><span class=\"T45\">Polydisulfide Peptides<\/span><span class=\"T46\">: antimicrobial peptides<\/span><span class=\"T47\">&#x200b;&#x200b;&nbsp;and dimerization zippers for proteins<\/span><span class=\"T48\">.<\/span><span class=\"T49\">&#x200b;&#x200b;&nbsp;<\/span><span class=\"T50\">Link<\/span><\/p><p class=\"P51\"><span class=\"T52\">Polyol Peptides:<\/span><span class=\"T53\">&#x200b;&#x200b;&nbsp;Self-assembly of synthetic amyloids of defined&#x200b;&#x200b;&nbsp;<\/span><span class=\"T54\">degree of&#x200b;&#x200b;&nbsp;<\/span><span class=\"T55\">oligomerization<\/span><span class=\"T56\">&#x200b;&#x200b;&nbsp;by r<\/span><span class=\"T57\">eversible&#x200b;&#x200b;&nbsp;<\/span><span class=\"T58\">esterification&#x200b;&#x200b;&nbsp;<\/span><a href=\"http:\/\/molecularbionic.bplaced.net\/?page_id=269&amp;preview=true\" target=\"_top\" title=\"\"><span class=\"T59\">Li<\/span><span id=\"_Hlt528675217\"\/><span id=\"_Hlt528675452\"\/><span class=\"T60\">n<\/span><span id=\"_Hlt528675074\"\/><span class=\"T61\">k<\/span><\/a><span class=\"T62\">&#x200b;&#x200b;&nbsp;<\/span><span class=\"T63\">of b<\/span><span class=\"T64\">oroxol<\/span><span class=\"T65\">e<\/span><span class=\"T66\">-<\/span><span class=\"T67\">linked p<\/span><span class=\"T68\">eptide<\/span><span class=\"T69\">s with polyhydroxylated peptides.&#x200b;&#x200b;&nbsp;<\/span><a href=\"http:\/\/molecularbionic.bplaced.net\/?page_id=277&amp;preview=true\" target=\"_top\" title=\"\"><span class=\"T70\">Li<\/span><span id=\"_Hlt528675416\"\/><span class=\"T71\">n<\/span><span class=\"T72\">k<\/span><\/a><\/p><p class=\"P73\"><span class=\"T74\">Biomolecular NMR&#x200b;&#x200b;&nbsp;<\/span><span class=\"T75\">S<\/span><span class=\"T76\">pectroscopy<\/span><span class=\"T77\">&#x200b;&#x200b;&nbsp;is the method of choice to i<\/span><span class=\"T78\">d<\/span><span class=\"T79\">e<\/span><span class=\"T80\">n<\/span><span class=\"T81\">tify the success of synthetic late-stage modifications of supramolecularer aggregates. NMR describes three dimensional structures and interactions in solution. Computer modeling completes the range of methods by picturing the molecular function.&#x200b;&#x200b;&nbsp;<\/span><a href=\"http:\/\/molecularbionic.bplaced.net\/?page_id=280&amp;preview=true\" target=\"_top\" title=\"\"><span class=\"T82\">Lin<\/span><span id=\"_Hlt528675362\"\/><span class=\"T83\">k<\/span><\/a><\/p><p class=\"P84\"><span class=\"T85\">The development of synthetic methods is at the center of the above-listed scientific questions. The target structures have technical applications like&#x200b;&#x200b;&nbsp;<\/span><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0968089616311907\" target=\"_top\" title=\"\"><span class=\"T86\">M<\/span><span class=\"T87\">edicinal&#x200b;&#x200b;&nbsp;<\/span><span class=\"T88\">C<\/span><span class=\"T89\">hemistry<\/span><\/a><span class=\"T90\">&#x200b;&#x200b;&nbsp;or aim at fundamental scientific questions like&#x200b;&#x200b;&nbsp;<\/span><a href=\"#2.Eight at one Stroke &#x2013; A Synthetic Tetra-Disulfide Peptide Epitope|outline\" target=\"_top\" title=\"\"><span class=\"T91\">P<\/span><span class=\"T92\">rebiotic&#x200b;&#x200b;&nbsp;<\/span><span class=\"T93\">C<\/span><span class=\"T94\">h<\/span><span class=\"T95\">emistry<\/span><\/a><span class=\"T96\">.<\/span><\/p><p class=\"P97\"><span>\u00a0<\/span><\/p><p class=\"P98\"><span class=\"T99\">If you are interested to join us working on one of the above projects, please contact Prof. Geyer<\/span><span class=\"T100\">&#x200b;&#x200b;&nbsp;<\/span><\/p><p class=\"P101\">&nbsp;<\/p><\/div><\/section><script>(function( $ ) {\n    \/\/footnotes\n    $('.defaultNote').children(\":first\").css('cursor', 'pointer');\n    $('.defaultNote').children(\":first\").click(function(){\n        var gotoID = '#' + $(this).parent().attr('id');\n        $('html, body').animate(\n            {\n              scrollTop: $('a[href=\"' + gotoID + '\"]').offset().top - 60,\n            },\n            250,\n            'linear'\n          )\n    });\n}(jQuery));\n\n\n<\/script><script>\nvar numFormat = \",.\";\n(function( $ ) {\n    \"use strict\";\n    \/\/do some cleaning on load\n    var sortCells = $('td[data-sorting], th[data-sorting]');\n    sortCells.each(function(){\n        var first = $(this).text().trim().charAt(0);\n        if (first == '@'){\n            var oldHTML = $(this).html();\n            var newHTML = oldHTML.replace('@', '');\n            $(this).html(newHTML);\n        } \n    });\n    function sortingTable(node, pos, ordBy){\n        var rows = node.children('tbody').children('tr').get();\n\n        rows.sort(function(a, b) {\n\n        var X = $(a).children('td').eq(pos).text().toUpperCase();\n        var Y = $(b).children('td').eq(pos).text().toUpperCase();\n        \n        if (numFormat != '.,'){\n            \/\/we are dealing with a different locale and we need to do some \n            \/\/transformation in numbers\n            X = convert2number(X);\n            Y = convert2number(Y);\n        } else {\n            X = X.replace(\/,\/g, '').replace(\/ \/g, '');\n            Y = Y.replace(\/,\/g, '').replace(\/ \/g, '');\n        }\n        var currencies = ['$', '\u00a5', '\u00a3', '\u20ac'];\n        var arrayLength = currencies.length;\n        var XX = X;\n        var YY = Y;\n        for (var i = 0; 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