Publikationsliste 2011-2015

[81] B. Eckhardt, W. Grosse, L.-O. Essen, A. Geyer. Structural characterization of a -turn mimic within a protein-protein interface. Proc. Natl. Acad. Sci. USA 2010, 107, 18336-18341.

 

[80] A. Bernecker, J. Ziomkowska, S. Heitmüller, R. Wieneke, A. Geyer, C. Steinem. Formation of silica precipitates on membrane surfaces in two and three dimensions. Langmuir 2010, 26, 13422-13428.

 

[79] A. Bernecker, R. Wieneke, R. Riedel, M. Seibt, A. Geyer, C. Steinem. Tailored synthetic polyamines for controlled biomimetic silica formation. J. Am. Chem. Soc. 2010, 132, 1023-1031.

 

[78] S. Enck, F. Kopp, M. A. Marahiel, A. Geyer. The reversible macrocyclization of tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization. Org. Biomol. Chem. 2010, 8, 559-563.

 

[77] S. Enck, F. Kopp, M. A. Marahiel, A. Geyer. The entropy balance of nostocyclopeptide macrocyclization analysed by NMR spectroscopy. ChemBioChem 2008, 9, 2597-2601.

 

[76] F. Di Pasquale, D. Fischer, D. Grohmann, T. Restle, A. Geyer, A. Marx. Opposed steric constraints in human DNA polymerase β and E. coli DNA polymerase I. J. Am. Chem. Soc. 2008, 130, 10748-10757.  

 

[75] M. Haack, S. Enck, H. Seger, A. Geyer, A. G. Beck-Sickinger. Pyridone dipeptide backbone scan to elucidate structural properties of a flexible peptide segment. J. Am. Chem. Soc. 2008, 130, 8326-8336. 

 

[74] R. Wieneke, S. Klein, A. Geyer, E. Loos. Structural and functional characterization of galactooligosaccharides in Nostoc commune: b-D-galactofuranosyl-(1 ->6)-[b -D-galactofuranosyl-(1-> 6)]2-b -D-1,4-anhydrogalactitol and b-(1-> 6)-galactofuranosylated homologues. Carbohydrate Research. 2007, 342, 2757-2765. 

 

[73] N. Fiori, A. Caporale, E. Schievano, S. Mammi, A. Geyer, P. Tremmel, A. Wittelsberger, I. Woznica, M. Chorev, E. Peggion. Structure-function relationship studies of PTH(1-11) analogues containing sterically hindered dipeptide mimetics.  J. Pept. Sci. 2007, 13, 504-512.

 

[72] M. P. Vélez, T. L. A. Verhoeven, C. Draing, S. Von Aulock, M. Pfitzenmaier, A. Geyer, I. Lambrichts, C. Grangette, B. Pot, J. Vanderleyden, S. C. J. De Keersmaecker. Functional analysis of D-alanylation of lipoteichoic acid in the probiotic strain Lactobacillus rhamnosus GG. Appl. Environ. Microbiol. 2007, 73, 3595-3604.

 

[71] S. Marimganti, R. Wieneke, A. Geyer, M. E. Maier. Synthesis and conformational analysis of geodiamolide analogues. Eur. J. Org. Chem., 2007, 2779-2790.

 

[70] D. Fischer, A. Geyer. NMR Analysis of bioprotective sugars: Sucrose and oligomeric (1->2)-a-d-glucopyranosyl-(1->2)-b-d-fructofuranosides. Top. Curr. Chem. 2007, 272, 169-185.

 

[69] R. Hörger, A. Geyer. A shape-persistent d,l-dipeptide building block for the assembly of rigidified oligopeptides. Org. Biomol. Chem. 2006, 4, 4491-4496.

 

[68] C. Draing, M. Pfitzenmaier, S. Zummo, G. Mancuso, A. Geyer, T. Hartung, S. von Aulock. Comparison of lipoteichoic acid from different serotypes of streptococcus pneumoniae. J. Biol. Chem. 2006, 281, 33849-33859.

 

[67] H. Seger, A. Geyer. Synthesis and diversification of pyridone dipeptide chromophores. Synthesis. 2006, 3224-3230.

 

[66] E. Palumbo, M. Deghorain, P. S. Cocconcelli, M. Kleerebezem, A. Geyer, T. Hartung, S. Morath, P. Hols. d-Alanyl ester depletion of teichoic acids in Lactobacillus plantarum results in a major modification of lipoteichoic acid composition and cell wall perforations at the septum mediated by the Acm2 autolysin. J. Bacteriol. 2006, 188, 3709-3715.

 

[65] R. Hörger, M. Marsch, A. Geyer, K. Harms. (1aS,1bS,4aR,4bR,7aS,10 R)-Methyl 1a,1b,4a,4b,7a,8,10,11-octahydro-8-oxo-bis(2-methyl-1,3-oxazino)[6,5,4- cd][4,5,6-de]thiazolo[3,2-a]azepine-10-carboxylate. Acta Cryst. E62. 2006, o846-o847.

 

[64] D. Fischer, A. Geyer, E. Loos. Occurrence of glucosylsucrose (-D-glucopyranosyl-(1->2)-α-D-glucopyranosyl-(1->2)--D-fructofuranoside) and glucosylated homologues in cyanobacteria: structural properties, cellular contents and possible function as thermoprotectants. FEBS Lett. 2006, 273, 137-149.

 

[63] D. Fischer, E. Loos, A. Geyer. Oligo-(1->2)--D-glucopyranosyl-(1->2)--D-fructofuranoside bilden kompakte Zuckerhelices. Angew. Chem. 2006, 118, 831-833.

Oligo-(1->2)-α-D-glucopyranosyl-(1->2)--D-fructofuranosides form tight sugar coils. Angew. Chem. Int. Ed. 2006, 45, 816-819.

 

[62] R. Hörger, M. Marsch, A. Geyer, K. Harms. (3aS,4S,4aS,7R,9S,9aS)-Methyl 4-benzyloxy-9-methylsulfonyloxy-2,2-dimethyl-8-oxooctahydro-1,3-dioxa-5-thia-7a-azacyclopenta[f]azulene-7-carboxylate toluene solvate. Acta Cryst. E61. 2005, o3447-o3448.

 

[61] H. Seger, S. Stempfhuber, M. Zabel, M. Marsch, A. Geyer, K. Harms. (3R)-Methyl 6-tert-butoxycarbonylamino-5-oxo-2,3-dihydro-5H-1,3-thiazolo[3,2-a]pyridine-3-carboxylate. Acta Cryst. E61. 2005, o2576-o2578.

 

[60] D. Fischer, A. Geyer. NMR spectroscopic characterization of the membrane affinity of polyols. Magn. Reson. Chem. 2005, 43, 893-901.

 

[59] R. Hörger, M. Marsch, A. Geyer, K. Harms. (3R,6S,7R,8R,9S,9aS)-Methyl 6,9-diacetoxy-7,8-diazidoperhydro-5-oxothiazolo[3,2-a]azepine-3-carboxylate. Acta Cryst. E61. 2005, o2191-o2192.

 

[58] K. Ágoston, A. Geyer. Regioselective conversion of the secondary hydroxyl groups of D-glucuronic acid without the requirement of O-protecting groups. Chem. Eur. J. 2005, 11, 6407-6413.

 

[57] P. Henneke, S. Morath, S. Uematsu, S. Weichert, M. Pfitzenmaier, O. Takeuchi, A. Mueller, C. Poyart, S. Akira, R. Berner, G. Teti, A. Geyer, T. Hartung, P. Trieu-Cuot, D. L. Kasper, D. T. Golenbock. Role of lipoteichoic acid in the phagocyte response to group B Streptococcus. J. Immunol. 2005, 174, 6449-6455.

 

[56] H. Seger, M. Marsch, A. Geyer, K. Harms.  (1R,3R)-Methyl 6-tert-butoxycarbonylamino-1,5-dioxo-2,3-dihydro-5H-1,3-thiazolo[3,2-a]pyridine-3-carboxylate. Acta Cryst. E61. 2005, o1798-o1799.

 

[55] P. Tremmel, A. Geyer.  Pyridone dipeptides – Synthesis of a novel peptide chromophore. Eur. J. Org. Chem. 2005, 3475-3481.

 

[54] P. Tremmel, A. Geyer. Coupled hydrogen bonding networks in polyhydroxylated peptides. Angew. Chem. 2004, 116, 5913-5915; Angew. Chem. Int. Ed. 2004, 43, 5789-5791.

 

[53] K. Agoston, A. Geyer. Synthesis of hydroxylated hexahydropyrrolo[2,1-b]thiazoles. Tetrahedron Lett. 2004, 45, 1895-1898.

 

[52] P. Tremmel, J. Brand, V. Knapp, A. Geyer. Side-chain functionalized dipeptides derived from 6,5-fused bicyclic thiazolidinlactams. Eur. J. Org. Chem. 2003, 878-884.

 

[51] A. Geyer, P. Tremmel. Rigid dipeptides mimicking the polyproline II helix. Peptides 2002, E. Benedetti and C. Pedone, Eds., Edizioni Ziino, Napoli, Italy 2002, 952-953.

 

[50] A. Geyer, P. Tremmel. Rigid dipeptides mimicking the polyproline II helix. J. Peptide Sci. 2002, 8, S59.

 

[49] P. Tremmel, A. Geyer. An oligomeric Ser-Pro dipeptide mimetic assuming the polyproline II helix conformation. J. Am. Chem. Soc. 2002, 124, 8548-8549.

 

[48] S. Sasmal, A. Geyer, M. E. Maier. Synthesis of cyclic peptidomimetics from aldol building blocks J. Org. Chem. 2002, 67, 6260-6263.

 

[47] S. Morath, A. Stadelmaier, A. Geyer, R. R. Schmidt, T. Hartung. Synthetic lipoteichoic from Staphylococcus aureus is a potent stimulus of cytokine release. J. Exp. Med. 2002, 195, 1635-1640.

 

[46] C. Gege, A. Geyer, R. R. Schmidt. Carbohydrate-carbohydrate recognition between LewisX blood group antigens, mediated by calcium ions. Eur. J. Org. Chem. 2002, 2475-2485.

 

[45] J. Michels, A. Geyer, V. Mocanu, W. Welte, A. L. Burlingame, M. Przybylski. Structure and functional characterization of the periplasmic N-terminal polypeptide domain of the sugar-specific ion channel protein (ScrY-Porin). Protein Science 2002, 11, 1565-1574.

 

[44] C. Gege, A. Geyer, R. R. Schmidt. Synthesis and molecular tumbling properties of Sialyl LewisX and derived neoglycolipids. Chem. Eur. J. 2002, 8, 2454-2463.

 

[43] A. Geyer. NMR-analysis of carbohydrate-carbohydrate interactions. - in: NMR spectroscopy of glycoconjugates, J. Jiménez-Barbero and T. Peters (Eds.) Wiley-VCH 2002 ISBN 3-527-30414-2, 275-288.

 

[42] F. Schaper, A. Geyer, H.-H. Brintzinger. Displacement of H3CB(C6F5)3- anions from zirconocene methyl cations by neutral ligand molecules: equilibria, kinetics, and mechanisms. Organometallics 2002, 21, 473-483.

 

[41] S. Morath, A. Geyer, I. Spreitzer, C. Hermann, T. Hartung. Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations. Infection and Immunity 2002, 70, 938-944.

 

[40] C. Hermann, C. Giammasi, A. Geyer, M. E. Maier. Synthesis of hapalosin analogs by solid-phase assembly of acyclic precursors. Tetrahedron 2001, 57, 8999-9010.

 

[39] A. Geyer, T. B. Fitzpatrick, P. D. Pawelek, K. Kitzing, A. Vrielink, S. Ghisla, P. Macheroux. Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma. Eur. J. Biochem. 2001, 268, 4044-4053.

 

[38] S. Morath, A. Geyer, T. Hartung. Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J. Exp. Med. 2001, 193, 393-397.

 

[37] S. Beck, S. Lieber, F. Schaper, A. Geyer, H.-H. Brintzinger. Anion exchange in alkyl-zirconocene borate ion pairs. Are solvated alkyl-zirconocene cations relevant intermediates? J. Am. Chem. Soc. 2001, 123, 1483-1489.

 

[36] A. Geyer, P. Tremmel. Polyol peptidomimetics. Peptides 2000, J. Martinez, J.-A. Fehrentz. (Eds.), 2001, EDK, Paris, 151-152.

 

[35] C. Hermann, G. C. G. Pais, A. Geyer, S. M. Kühnert, M. E. Maier. Total synthesis of hapalosin and two ring expanded analogs. Tetrahedron 2000, 56, 8461-8471.

 

[34] A. Geyer, P. Tremmel. Polyol peptidomimetics. J. Peptide Sci. 2000, 6, S83.

 

[33] N. Schneider, F. Schaper, K. Schmidt, R. Kirsten, A. Geyer, H.-H. Brintzinger. Zirconocene complexes with cyclopenta[l]phenanthrene ligands: Synthesis, structural dynamics and properties as olefin polymerization catalysts. Organometallics 2000, 19, 3597-3604.

 

[32] A. Geyer, C. Gege, R. R. Schmidt. Calciumabhängige Kohlenhydrat-Kohlenhydrat-Erkennung zwischen LewisX Blutgruppenantigenen. Angew. Chem. 2000, 112, 3382-3385.

Calcium dependent carbohydrate-carbohydrate recognition of LewisX blood group antigens. Angew. Chem. Int. Ed. 2000, 39, 3246-3249.

 

[31] M. Weng, A. Geyer, A. Friemel, J. C. Jochims, M. Lutz. Cycloaddition reactions of 1,3-Diaza-2-azoniaallene salts and glycals. J. Prakt. Chem. 2000, 342, 486-493.

 

[30] A. Geyer. Polyol Shapes, Habilitationsschrift, Konstanz 2000.

 

[29] A. Geyer, F. Moser. Polyol peptidomimetics. Eur. J. Org. Chem. 2000, 1113-1120.

 

[28] S. Beck, A. Geyer, H.-H. Brintzinger. Diffusion coefficients of zirconocene-borate ion pairs studied by pulsed field gradient NMR - evidence for ion quadruples in benzene solutions J. Chem. Soc., Chem. Commun. 1999, 2477-2478.

 

[27] M. Müller, U. Huchel, A. Geyer, R. R. Schmidt. Efficient intramolecular glycosylation supported by a rigid spacer. J. Org. Chem. 1999, 64, 6190-6201.

 

[26] A. Geyer, M. Müller, R. R. Schmidt. A glycosidic linkage constrained to the “anti” conformation. J. Am. Chem. Soc. 1999, 121, 6312-6313.

 

[25] A. Geyer, C. Gege, R. R. Schmidt. Kohlenhydrat-Kohlenhydrat-Erkennung der LewisX-Glycoconjugaten. Angew. Chem. 1999, 111, 1569-1571.

Carbohydrate-carbohydrate recognition between LewisX-glycolipids. Angew. Chem. Int. Ed. 1999, 38, 1466-1468.

 

[24] H. W. Lee, C. H. Oh, A. Geyer, W. Pfleiderer, Y. S. Park. Characterization of a novel unconjugated pteridine glycoside, cyanopterin, in Synechocystis sp. PCC 6803. Biochim. Biophys. Acta/Bioenergetics 1999, 1410, 61-70.

 

[23] A. Geyer, U. Huchel, R. R. Schmidt. Conformational analysis of model structures for intramolecular glycoside bond formation. Magn. Reson. Chem. 1999, 37, 145-148.

 

[22] A. Geyer, S. Reinhardt, R. R. Schmidt. NMR analysis of a rigid carbohydrate structural motif. Polish J. Chem. 1999, 73, 181-192.

 

[21] A. Geyer, D. Bockelmann, K. Weissenbach, H. Fischer. Synthesis and structural analysis of a hydrophilic b-turn mimetic. Tetrahedron Lett. 1999, 40, 477-478.

 

[20] N. A. Al-Masoudi, Y. A. Al-Soud, A. Geyer. Synthesis and spectroscopic analysis of acyclic C-nucleosides and homo-C-analogues from 1-(chloroalkyl)-1-aza-2-azoniaallene salts. Tetrahedron 1999, 55, 751-759.

 

[19] N. A. Al-Masoudi, Y. A. Al-Soud, A. Geyer. 1H- and 13C-NMR study of some 6,7-dihaloquinolone nucleosides and their derivatives. Spectroscopy Letters 1998, 31, 1031-1038.

 

[18] J. Rademann, A. Geyer, R. R. Schmidt. Festphasensynthese einer verzweigten Pentasaccharideinheit, die in den meisten komplexen N-Glycanen vorkommt. Angew. Chem. 1998, 110, 1309-1313.

Solid-phase supported synthesis of the branched pentasaccharide moiety that occurs in most complex type N-Glycan chains. Angew. Chem. Int. Ed. 1998, 37, 1241-1245.

 

[17] H. Fischer, K. Weißenbach, C. Karl, A. Geyer. Diastereoselective substitution of PR3 for CO in carbene(dicarbonyl)cyclopentadienyl complexes of manganese – synthesis of (SMn) and (RMn)-[Cp(CO)PR3Mn=C(OR*)R´] complexes. Eur. J. Inorg. Chem. 1998, 339-347.

 

[16] H.-R. H. Damrau, A. Geyer, M.-H. Prosenc, A. Weeber, F. Shaper, H.-H. Brintzinger. ansa-Metallocene derivatives XLI. Chiral ansa-magnesocene complexes – synthesis, crystal structures and structural dynamics in solution. J. Organomet. Chem. 1998, 553, 331-343.

 

[15] A. Geyer, S. Reinhardt, G. Bendas, U. Rothe, R. R. Schmidt. C2-Symmetric Lewis antigen mimetics exhibiting the common structural motif. J. Am. Chem. Soc. 1997, 119, 11707-11708.

 

[14] U. K. Saha, L. S. Griffith, J. Rademann, A. Geyer, R. R. Schmidt. An N-acetylglucosamine containing glycopeptide – synthesis and structure assignment. Carbohydr. Res. 1997, 304, 21-28.

 

[13] A. Geyer, G. Hummel, T. Eisele, S. Reinhardt, R. R. Schmidt. Structural motifs of the dimeric Lewis glycolipids as determined by NMR spectroscopy and molecular dynamics simulations. Chem. Eur. J. 1996, 2, 981-988.

 

[12] H. Streicher, A. Geyer, R. R. Schmidt. C-Disaccharides of ketoses. Chem. Eur. J. 1996, 2, 502-510.

 

[11] H. Kessler, B. Diefenbach, D. Finsinger, A. Geyer, M. Gurrath, S. L. Goodman, G. Hölzemann, R. Haubner, A. Jonczyk, G. Müller, E. Graf v. Roedern, J. Wermuth. Design of superactive and selective integrin receptor antagonists containing the RGD sequence. Lett. Pept. Sci. 1995, 2, 155-160.

 

[10] Z.-H. Jiang, A. Geyer, R. R. Schmidt. Das makrolidische Glycolipid Calonyctin A, ein Pflanzenwachstumsregulator – Synthese, Konfigurations-zuordnung und Konformationsanalyse in micellarer Lösung. Angew. Chem. 1995, 107, 2730-2734.

The macrolidic glycolipid Calonyctin A, a plant growth regulator: synthesis, structural assignment, and conformational analysis in micellar solution. Angew. Chem. Int. Ed. Engl. 1995, 34, 2520-2524.

 

[9] A. Geyer, W. Pfleiderer. Stereochemistry of drosopterins. Pteridines 1995, 6, 22-23.

 

[8] D. F. Mierke, A. Geyer, H. Kessler. Coupling constants and hydrogen bonds as experimental restraints in a distance geometry refinement protocol. Int. J. Peptide Protein Res. 1994, 44, 325-331.

 

[7] A. Geyer, G. Müller, H. Kessler. Conformational analysis of a cyclic RGD peptide containing a [CH2-NH] bond: a positional shift in backbone structure caused by a single dipeptide mimetic. J. Am. Chem. Soc. 1994, 116, 7735-7743.

 

[6] H. Kessler, E. Graf v. Roedern, E. Lohof, R. Haubner, A. Geyer, V. Wittmann. New peptidomimetics and conformational consequences. - in: Proc. of the 5th Akabori Conference, E. Wünsch (Ed.) Max-Planck-Gesellschaft, München, Germany 1994, 110-115.

 

[5] A. Geyer. Peptidbindungsisostere: Synthese und Strukturanalyse von Thioamidbindungen und reduzierten Amidbindungen in Peptiden. Dissertation, München 1994.

 

[4] A. Geyer, D. F. Mierke, C. Unverzagt, H. Kessler. Synthesis of cyclic thiohexapeptides. Peptides 1992, C. H. Schneider, A. N. Eberle (Eds.) 1993 ESCOM Science Publishers B. V., Leiden, Netherlands, 599-600.

 

[3] C. Unverzagt, A. Geyer, H. Kessler. Racemisierungsfreie Ketten-verlängerung von Thiodipeptiden mit Proteasen. Angew. Chem. 1992, 104, 1231-1233.

Chain elongation of thiopeptides with proteases. Angew. Chem. Int. Ed. Engl. 1992, 31, 1229-1230.

 

[2] H. Kessler, H. Matter, A. Geyer, H.-J. Diehl, M. Köck, G. Kurz, F. R. Opperdoes, M. Callens, R. K. Wierenga. Selektive Inhibierung der trypanosomalen Triosephosphat-Isomerase durch ein Thiopeptid. Angew. Chem. 1992, 104, 343-345.

Selective inhibition of trypanosomal triosephosphate isomerase by a thiopeptide. Angew. Chem. Int. Ed. Engl. 1992, 31, 328-330.

 

[1] H. Kessler, A. Geyer, H. Matter, M. Köck. Unusual thionation of a cyclic hexapeptide. Int. J. Peptide Protein Res. 1992, 40, 25-40.